Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

- Vanaja et al., 2016, Cell 165 , 1106–1119

Summary

1. Gram-negative bacteria secrete outer membrane vesicles (OMV⁽¹⁾) that deliver lipopolysaccharide (LPS) to the host’s cell via endocytosis.

2. LPS released from early endosome then triggers noncanonical inflammasome response: caspase-11 and pyroptosis ⁽²⁾.

Significance

This study showed the missing gap between bacteria and host cell.

My feedback

Maybe we can find the compound to chelator the OMV or target the specific LPS in the gram-negative bacteria to reduce their chance to enter host cell.

Supplement

(1) OMVs are a programmed product, which enable the bacteria to communicate with host cells and deliver their products intracellularly to modulate cellular functions.

(2) Pyroptosis is a form of Programmed cell death associated with Antimicrobial responses during Inflammation. In contrast to apoptosis, pyroptosis requires the function of Caspase-1.